Targeting tumor vasculature with novel Listeria-based vaccines directed against CD105
نویسندگان
چکیده
منابع مشابه
Targeting cancer vasculature via endoglin/CD105: a novel antibody-based diagnostic and therapeutic strategy in solid tumours.
Endoglin/CD105 is well acknowledged as being the most reliable marker of proliferation of endothelial cells, and it is overexpressed on tumour neovasculature. Our current knowledge of its structure, physiological role, and tissue distribution suggests that targeting of endoglin/CD105 is a novel and powerful diagnostic and therapeutic strategy in human malignancies, through the imaging of tumour...
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The selective targeting of established tumor vasculature represents an attractive new anticancer drug strategy, distinct from inhibiting angiogenesis. This is based on the concept that, in contrast to targeting individual tumor cells, the killing of relatively few vascular endothelial cells could result in the death of a large area of tumor (from lack of oxygen and nutrients), drug delivery to ...
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ژورنال
عنوان ژورنال: Cancer Immunology, Immunotherapy
سال: 2011
ISSN: 0340-7004,1432-0851
DOI: 10.1007/s00262-011-1002-x